Antibiotics / Selective agents
ACYCLOVIR
מק"ט: A0183.1000
- 1 Gram
- CAS number 59277-89-3
- Molecular weight C8H11N5O3 = 225.2
- Acyclovir inhibits viral DNA synthesis by selective interaction with two distinct viral proteins. Cellular uptake and initial
- phosphorylation are facilitated by thymidine kinase. Cellular enzymes convert the monophosphate to acyclovir triphosphate and
- compete for endogeneous deoxyguanosine triphos-phate (dGTP). Acyclovir triphosphate competively inhibits viral DNA
- polymerases and, to a much smaller extent, cellular DNA polymerases. Acyclovir triphosphate is also incorporated into viral DNA,
- where it acts as a chain terminator because of the lack of 3’-hydroxyl group. By a mechanism termed suicide inactivation, the
- terminated DNA template containing acyclovir binds the enzym and leads to irreversible inactivation of the DNA polymerase.
- Storage condition
- Store at room temperature
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